| Primary Identifier | MGI:107566 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16579 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables intraciliary transport particle B binding activity. Involved in microtubule-based process. Acts upstream of or within several processes, including negative regulation of apoptotic process; negative regulation of neuroblast proliferation; and positive regulation of calcium-dependent cell-cell adhesion. Located in several cellular components, including cytoskeleton; periciliary membrane compartment; and photoreceptor cell cilium. Part of kinesin II complex. Is expressed in embryo mesenchyme; heart; nervous system; and sensory organ. Orthologous to human KIFAP3 (kinesin associated protein 3). PHENOTYPE: About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
