Primary Identifier | MGI:1098246 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 100042150 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables receptor ligand activity. Involved in ERBB2-ERBB3 signaling pathway and ERBB4-ERBB4 signaling pathway. Is active in extracellular space. Is expressed in epidermis; heart; mammary gland primordium; nervous system; and surface ectoderm. Orthologous to human NRG2 (neuregulin 2). PHENOTYPE: About one third of mice homozygous for a knock-out allele die prior to weaning in the absence of cardiac defects or other morphological abnormalities. Homozygotes display an early but transient postnatal growth deficit and reduced reproductive capacity. [provided by MGI curators] |