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Allele : Camk2a<tm1Sva> calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, Alcino Silva

Primary Identifier  MGI:1857279 Allele Type  Targeted
Attribute String  Null/knockout Gene  Camk2a
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A 130 bp DNA segment encoding the inhibitory domain and five amino acids of the calmodulin-binding domain was replaced with a neomycin selection cassette. Northern blot analysis on brain RNA derived from homozygous mice confirmed that no detectable transcript is produced from this allele. Western blot analysis on forebrain samples from homozygous mice demonstrated that no detectable protein is expressed from this allele.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Camk2a<tm1>,
  • Camk2a<tm1>,
  • alphaCaMKII-,
  • alphaCaMKII<null>,
  • alpha-CaMKII-,
  • alphaCaMKII-,
  • alpha-CaMKII-,
  • alphaCaMKII<null>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

27 Publication categories

Trail: Allele