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Allele : Gt(ROSA)26Sor<tm1(tTA,tetO-Mtor*D2338A,-IRES-EGFP)Ebm> gene trap ROSA 26, Philippe Soriano; transgene insertion 1, Ernesto Bernal-Mizrachi
Primary Identifier  MGI:6429840 Allele Type  Targeted
Attribute String  Inducible, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  Not Specified
Induced With  doxycycline/tetracycline Is Recombinase  false
Is Wild Type  false
molecularNote  The transgenic construct inserted into the GT(ROSA)26Sor locus contains a splice-acceptor sequence, loxP-flanked neomycin selection cassette, a tetracycline transactivator (tTA) gene, insulator sequence, CMV promoter responsive to tTA, rabbit -globin intron, Mtor cDNA encoding a kinase dead protein, an internal ribosome entry site, and an enhanced green fluorescence protein (EGFP) cDNA. Expression of the tetracycline transactivator is turned on upon Cre-mediated recombination, and removal of the neomycin selection cassette induces Mtor expression in the absence of doxycycline.
  • mutations:
  • Insertion
  • synonyms:
  • KD-mTOR,
  • KD-mTOR
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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6 Publication categories

Trail: Allele




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