| First Author | Wang Q | Year | 2021 |
| Journal | Nature | Volume | 600 |
| Issue | 7888 | Pages | 314-318 |
| PubMed ID | 34819664 | Mgi Jnum | J:337627 |
| Mgi Id | MGI:7287963 | Doi | 10.1038/s41586-021-04127-5 |
| Citation | Wang Q, et al. (2021) IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature 600(7888):314-318 |
| abstractText | Thermogenesis in brown and beige adipose tissue has important roles in maintaining body temperature and countering the development of metabolic disorders such as obesity and type 2 diabetes(1,2). Although much is known about commitment and activation of brown and beige adipose tissue, its multiple and abundant immunological factors have not been well characterized(3-6). Here we define a critical role of IL-27-IL-27Ralpha signalling in improving thermogenesis, protecting against diet-induced obesity and ameliorating insulin resistance. Mechanistic studies demonstrate that IL-27 directly targets adipocytes, activating p38 MAPK-PGC-1alpha signalling and stimulating the production of UCP1. Notably, therapeutic administration of IL-27 ameliorated metabolic morbidities in well-established mouse models of obesity. Consistently, individuals with obesity show significantly decreased levels of serum IL-27, which can be restored after bariatric surgery. Collectively, these findings show that IL-27 has an important role in orchestrating metabolic programs, and is a highly promising target for anti-obesity immunotherapy. |
