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Publication : Cloning and expression of a rat brain basic helix-loop-helix factor.

First Author  Kawakami H Year  1996
Journal  Biochem Biophys Res Commun Volume  221
Issue  1 Pages  199-204
PubMed ID  8660336 Mgi Jnum  J:32510
Mgi Id  MGI:80004 Doi  10.1006/bbrc.1996.0569
Citation  Kawakami H, et al. (1996) Cloning and expression of a rat brain basic helix-loop-helix factor. Biochem Biophys Res Commun 221(1):199-204
abstractText  We cloned two rat cDNAs of brain basic helix-loop-helix factor 1 (BHF1). These have an identical coding region, contain 357 amino acids and exhibit 94.6% identity to MATH-2/NEX1 in the basic helix-loop-helix region. BHF1mRNAs are dominantly expressed in the brain particularly in the cerebellum, in the adult bovine, rat and mouse. Two shorter BHF1mRNAs (1.6 kb and 1.8 kb) were also detected in the mouse embryo, and these decreased in the developmental process. These results suggest that BHF1 may play important roles in cerebellum-specific functions and development of neurons.
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