| First Author | Hermeking H | Year | 2000 |
| Journal | Proc Natl Acad Sci U S A | Volume | 97 |
| Issue | 5 | Pages | 2229-34 |
| PubMed ID | 10688915 | Mgi Jnum | J:60924 |
| Mgi Id | MGI:1354092 | Doi | 10.1073/pnas.050586197 |
| Citation | Hermeking H, et al. (2000) Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A 97(5):2229-34 |
| abstractText | The prototypic oncogene c-MYC encodes a transcription factor that can drive proliferation by promoting cell-cycle reentry. However, the mechanisms through which c-MYC achieves these effects have been unclear. Using serial analysis of gene expression, we have identified the cyclin-dependent kinase 4 (CDK4) gene as a transcriptional target of c-MYC. c-MYC induced a rapid increase in CDK4 mRNA levels through four highly conserved c-MYC binding sites within the CDK4 promoter. Cell-cycle progression is delayed in c-MYC-deficient RAT1 cells, and this delay was associated with a defect in CDK4 induction. Ectopic expression of CDK4 in these cells partially alleviated the growth defect. Thus, CDK4 provides a direct link between the oncogenic effects of c-MYC and cell-cycle regulation. |
