| First Author | Becker RM | Year | 1998 |
| Journal | Genomics | Volume | 54 |
| Issue | 1 | Pages | 70-8 |
| PubMed ID | 9806831 | Mgi Jnum | J:51474 |
| Mgi Id | MGI:1316803 | Doi | 10.1006/geno.1998.5539 |
| Citation | Becker RM, et al. (1998) Identification of mammaglobin B, a novel member of the uteroglobin gene family. Genomics 54(1):70-8 |
| abstractText | In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue. Copyright 1998 Academic Press. |
