| Primary Identifier | MGI:2144023 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 103583 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of non-canonical NF-kappaB signal transduction; and protein polyubiquitination. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system and yolk sac. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic growth arrest and complete embryonic lethality before E10.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
