| First Author | Suzuki H | Year | 2005 |
| Journal | Biochem Biophys Res Commun | Volume | 326 |
| Issue | 1 | Pages | 242-8 |
| PubMed ID | 15567177 | Mgi Jnum | J:94162 |
| Mgi Id | MGI:3511401 | Doi | 10.1016/j.bbrc.2004.11.016 |
| Citation | Suzuki H, et al. (2004) The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Biochem Biophys Res Commun 326(1):242-8 |
| abstractText | The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19(ARF) or human p14(ARF) binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression. |
