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Publication : Meet the terminator: The phosphatase PP2A puts brakes on IRF-3 activation.

First Author  Chattopadhyay S Year  2014
Journal  Mol Cell Volume  54
Issue  2 Pages  210-1
PubMed ID  24766884 Mgi Jnum  J:214766
Mgi Id  MGI:5603979 Doi  10.1016/j.molcel.2014.04.008
Citation  Chattopadhyay S, et al. (2014) Meet the terminator: The phosphatase PP2A puts brakes on IRF-3 activation. Mol Cell 54(2):210-1
abstractText  Cellular interferon response to microbial infection is transient. In a recent paper in Immunity, Long et al. (2014) identify protein phosphatase 2A (PP2A) as a deactivator of phospho-interferon regulatory factor 3, the key transcription factor for interferon synthesis, thus providing one basis for the observed transiency.
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