| First Author | Lindeman GJ | Year | 1994 |
| Journal | Immunity | Volume | 1 |
| Issue | 6 | Pages | 517-27 |
| PubMed ID | 7895160 | Mgi Jnum | J:119623 |
| Mgi Id | MGI:3702852 | Doi | 10.1016/1074-7613(94)90094-9 |
| Citation | Lindeman GJ, et al. (1994) B-lymphoid to granulocytic switch during hematopoiesis in a transgenic mouse strain. Immunity 1(6):517-27 |
| abstractText | B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes that promote lymphocyte survival or proliferation. Bitransgenic myc/max 41 mice developed pre-B cell lymphoma. An accompanying massive granulocytosis unexpectedly proved to be clonally derived from the pre-B lymphoma cells. These observations suggest that B lymphopoiesis in max 41 mice has been diverted to granulocyte production. Since neither cell type expressed the transgene, this novel lymphomyeloid deviation probably reflects insertional alteration of a hematopoietic regulatory gene. |
