| First Author | Hernández EC | Year | 2002 |
| Journal | Immunogenetics | Volume | 54 |
| Issue | 9 | Pages | 645-53 |
| PubMed ID | 12466897 | Mgi Jnum | J:81220 |
| Mgi Id | MGI:2448368 | Doi | 10.1007/s00251-002-0512-2 |
| Citation | Hernandez EC, et al. (2002) Identification, cloning, and sequencing of different cytokine genes in four species of owl monkey. Immunogenetics 54(9):645-53 |
| abstractText | Non-human primates could prove to be suitable models for the study of infectious diseases such as malaria, tuberculosis, and hepatitis; the molecules of their immune systems are in the process of being fully characterized. Due to the relevance of cytokines in the modulation of the immune response, a molecular analysis of these proteins in non-human primates from the Aotus genus was carried out. Peripheral blood mononuclear cells from four species of Aotusmonkey were obtained and their mRNAs for interleukin-2 (IL-2), IL-4, IL-6, IL-10, interferon-gamma (IFN), and tumor necrosis factor (TNF)-alpha were characterized. This study shows a high degree of conservation between nucleotide and amino acid sequences of cytokines from different Aotus species and those from humans. The TNF-alpha molecules were identical in amino acid sequences for both. |
