| First Author | Palayoor ST | Year | 1984 |
| Journal | J Neurochem | Volume | 42 |
| Issue | 6 | Pages | 1771-4 |
| PubMed ID | 6233395 | Mgi Jnum | J:7459 |
| Mgi Id | MGI:55929 | Doi | 10.1111/j.1471-4159.1984.tb12771.x |
| Citation | Palayoor ST, et al. (1984) Genetic association between Ca2+-ATPase activity and audiogenic seizures in mice. J Neurochem 42(6):1771-4 |
| abstractText | Ca2+-ATPase activity was studied in fresh brain stem homogenates of the audiogenic seizure (AGS)-resistant C57BL/6 and AGS-susceptible DBA/2 inbred strains and in 21 B6 X D2 recombinant inbred strains. A highly significant negative correlation was found between Ca2+-ATPase activity and AGS susceptibility among these strains. In general, strains with low Ca2+-ATPase activities were more AGS-susceptible than strains with high activities. Further, Ca2+-ATPase activity appears to be influenced by a major gene associated with the Ah locus. This gene is designated Caa for Ca2+-ATPase activity and is different from Ias, which is closely linked to the Ah locus. Ias influences AGS spread by a yet unknown biochemical mechanism, whereas Caa may influence AGS susceptibility by regulating Ca2+-ATPase activity in brain tissue. |
