| First Author | Belzung C | Year | 1994 |
| Journal | Pharmacol Biochem Behav | Volume | 49 |
| Issue | 2 | Pages | 433-6 |
| PubMed ID | 7824561 | Mgi Jnum | J:20926 |
| Mgi Id | MGI:68985 | Doi | 10.1016/0091-3057(94)90445-6 |
| Citation | Belzung C, et al. (1994) PD135158, a CCK-B antagonist, reduces state, but not trait anxiety in mice. Pharmacol Biochem Behav 49(2):433-6 |
| abstractText | It has recently been proposed that Balb/c neophobic responses in a free exploratory paradigm are related to trait anxiety, while the behavior of mice in the light/dark choice test paradigm is related to state anxiety. The purpose of this study was to assess the action of the CCK-B receptor antagonist PD135158 in both models. Results show that PD135158 was effective in the light/dark choice test but not on the Balb/c neophobic reactions in the free exploratory situation. It is suggested that PD135158 is specially effective in state anxiety induced by fear provoking situations. |
