| First Author | Olson LE | Year | 2011 |
| Journal | Dev Cell | Volume | 20 |
| Issue | 6 | Pages | 815-26 |
| PubMed ID | 21664579 | Mgi Jnum | J:173602 |
| Mgi Id | MGI:5049790 | Doi | 10.1016/j.devcel.2011.04.019 |
| Citation | Olson LE, et al. (2011) PDGFRbeta Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Dev Cell 20(6):815-26 |
| abstractText | Mural cells (pericytes and vascular smooth muscle cells) provide trophic and structural support to blood vessels. Vascular smooth muscle cells alternate between a synthetic/proliferative state and a differentiated/contractile state, but the dynamic states of pericytes are poorly understood. To explore the cues that regulate mural cell differentiation and homeostasis, we have generated conditional knockin mice with activating mutations at the PDGFRbeta locus. We show that increased PDGFRbeta signaling drives cell proliferation and downregulates differentiation genes in aortic vascular smooth muscle. Increased PDGFRbeta signaling also induces a battery of immune response genes in pericytes and mesenchymal cells and inhibits differentiation of white adipocytes. Mural cells are emerging as multipotent progenitors of pathophysiological importance, and we identify PDGFRbeta signaling as an important in vivo regulator of their progenitor potential. |
