| First Author | Dahal E | Year | 2020 |
| Journal | Sci Rep | Volume | 10 |
| Issue | 1 | Pages | 20505 |
| PubMed ID | 33239703 | Mgi Jnum | J:299710 |
| Mgi Id | MGI:6491062 | Doi | 10.1038/s41598-020-77554-5 |
| Citation | Dahal E, et al. (2020) Label-free X-ray estimation of brain amyloid burden. Sci Rep 10(1):20505 |
| abstractText | Amyloid plaque deposits in the brain are indicative of Alzheimer's and other diseases. Measurements of brain amyloid burden in small animals require laborious post-mortem histological analysis or resource-intensive, contrast-enhanced imaging techniques. We describe a label-free method based on spectral small-angle X-ray scattering with a polychromatic beam for in vivo estimation of brain amyloid burden. Our findings comparing 5XFAD versus wild-type mice correlate well with histology, showing promise for a fast and practical in vivo technique. |
