| First Author | Ruggero D | Year | 2004 |
| Journal | Nat Med | Volume | 10 |
| Issue | 5 | Pages | 484-6 |
| PubMed ID | 15098029 | Mgi Jnum | J:89878 |
| Mgi Id | MGI:3041885 | Doi | 10.1038/nm1042 |
| Citation | Ruggero D, et al. (2004) The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 10(5):484-6 |
| abstractText | The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt. |
