| First Author | Beamer WG | Year | 1998 |
| Journal | Cancer Res | Volume | 58 |
| Issue | 16 | Pages | 3694-9 |
| PubMed ID | 9721880 | Mgi Jnum | J:49710 |
| Mgi Id | MGI:1278042 | Citation | Beamer WG, et al. (1998) Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res 58(16):3694-9 |
| abstractText | Spontaneous juvenile ovarian granulosa cell (GC) tumors that occur in young girls are similar to GC carcinomas that develop in SWR-derived inbred mice. We analyzed female offspring from a series of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility. Intercross F-2 female mice were produced by reciprocal matings of (SWR x SJL)F-1 and (SJL x SWR)F-1 parents. Tumorigenesis in these: F-2 mice as well as in SWXJ recombinant inbred and congenic strains of mice derived from SWR and SJL showed significant (P < 0.001) association with Gct1, a dominant susceptibility locus on chromosome (CHR)4 and with Gct2 on CHR 12. Suggestive (P < 0.01) association was found with Gct3 on CHR 15. A fourth susceptibility locus, Gct4 on CHR X, was demonstrated with a strong parent-of-origin effect associated with the paternal genotype. Imprinting and complex interactions among these four loci combine to establish the probability for GC tumorigenesis in this mouse model. |
