| First Author | Pawelek JM | Year | 2008 |
| Journal | Nat Rev Cancer | Volume | 8 |
| Issue | 5 | Pages | 377-86 |
| PubMed ID | 18385683 | Mgi Jnum | J:136151 |
| Mgi Id | MGI:3795323 | Doi | 10.1038/nrc2371 |
| Citation | Pawelek JM, et al. (2008) Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. Nat Rev Cancer 8(5):377-86 |
| abstractText | The causes of metastasis remain elusive despite vast information on cancer cells. We posit that cancer cell fusion with macrophages or other migratory bone marrow-derived cells (BMDCs) provides an explanation. BMDC-tumour hybrids have been detected in numerous animal models and recently in human cancer. Molecular studies indicate that gene expression in such hybrids reflects a metastatic phenotype. Should BMDC-tumour fusion be found to underlie invasion and metastasis in human cancer, new approaches for therapy would surely follow. |
