| First Author | Meno C | Year | 1998 |
| Journal | Cell | Volume | 94 |
| Issue | 3 | Pages | 287-97 |
| PubMed ID | 9708731 | Mgi Jnum | J:49052 |
| Mgi Id | MGI:1276622 | Doi | 10.1016/s0092-8674(00)81472-5 |
| Citation | Meno C, et al. (1998) lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94(3):287-97 |
| abstractText | lefty-1, leffy-2 and nodal are expressed on the left side of developing mouse embryos and are implicated in left- right (L-R) determination. The role of lefty-1 was examined by analyzing mutant mice lacking this gene. The lefty-1-deficient mice showed a variety of L-R positional defects in visceral organs. Unexpectedly, however, the most common feature of lefty-1(-/-) mice was thoracic left isomerism (rather than right isomerism). The lack of lefty- 1 resulted in bilateral expression of nodal, lefty-2, and Pitx2 (a homeobox gene normally expressed on the left side). These observations suggest that the role of lefty-1 is to restrict the expression of lefty-2 and nodal to the left side, and that lefty-2 or nodal encodes a signal for ''leftness.'' |
