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Protein Coding Gene : Dazl deleted in azoospermia-like

Primary Identifier  MGI:1342328 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  13164
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables identical protein binding activity; mRNA 3'-UTR binding activity; and translation activator activity. Involved in positive regulation of translational initiation. Acts upstream of or within female meiosis II; oocyte maturation; and positive regulation of meiotic nuclear division. Located in cytoplasm; nucleus; and ribosome. Is expressed in several structures, including central nervous system; early embryo; gonad; mesonephros; and sensory organ. Orthologous to several human genes including DAZL (deleted in azoospermia like).
PHENOTYPE: Males homozygous for a targeted null mutation exhibit sterility with a complete absence of mature germ cells. In mutants, few spermatogonia enter meiosis, and those that do fail to proceed beyond pachytene. [provided by MGI curators]
  • synonyms:
  • MGI:98816,
  • MGD-MRK-15214,
  • Dazla,
  • Tpx2,
  • deleted in azoospermia-like,
  • Daz-like,
  • MGD-MRK-35375,
  • Tpx-2,
  • MGI:106914,
  • testis specific gene 2,
  • DAZ-like autosomal,
  • Dazl,
  • MGD-MRK-15212

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For