| First Author | Nielsen AA | Year | 2009 |
| Journal | Gene | Volume | 442 |
| Issue | 1-2 | Pages | 55-62 |
| PubMed ID | 19376211 | Mgi Jnum | J:149677 |
| Mgi Id | MGI:3848855 | Doi | 10.1016/j.gene.2009.04.003 |
| Citation | Nielsen AA, et al. (2009) Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis. Gene 442(1-2):55-62 |
| abstractText | Neurogranin (Nrgn) is a highly expressed brain-specific protein, which sequesters calmodulin at low Ca(2+)-levels. We report here on retroviral activation of the Nrgn gene in tumors induced by the T-cell lymphomagenic SL3-3 murine leukemia virus. We have performed a systematic expression analysis of Nrgn in various mouse tissues and SL3-3 induced T-cell tumors. This demonstrated that insertional activation of Nrgn increased RNA and protein expression levels to that observed in brain. Furthermore, elevated Nrgn expression was also observed in some T-cell tumors with no detected provirus integrations into this genomic region. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice. |
