Primary Identifier | MGI:1309528 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 17931 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable several functions, including 14-3-3 protein binding activity; phosphatase regulator activity; and protein kinase binding activity. Acts upstream of or within cellular response to xenobiotic stimulus and regulation of nucleocytoplasmic transport. Located in A band and Z disc. Is expressed in several structures, including corpus striatum; genital tubercle epithelium; head mesenchyme; urethra epithelium; and urothelium. Orthologous to human PPP1R12A (protein phosphatase 1 regulatory subunit 12A). PHENOTYPE: Homozygous null mice die before E7.5. Mice homozygous for a smooth muscle specific conditional knockout exhibit altered intestinal smooth muscle contractility. [provided by MGI curators] |