Primary Identifier | MGI:1098268 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 16573 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable several functions, including ATP hydrolysis activity; JUN kinase binding activity; and microtubule lateral binding activity. Involved in positive regulation of GABAergic synaptic transmission; regulation of modification of synapse structure, modulating synaptic transmission; and stress granule disassembly. Acts upstream of or within several processes, including cellular response to type II interferon; mitocytosis; and organelle transport along microtubule. Located in several cellular components, including ciliary rootlet; mitochondrion; and phagocytic vesicle. Is active in postsynaptic cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KIF5B (kinesin family member 5B). PHENOTYPE: Mice homozygous for disruptions in this gene die as embryos during organogenesis, exhibit growth retardation and fail to turn during gastrulation. [provided by MGI curators] |