| First Author | Feng Q | Year | 2006 |
| Journal | Nat Cell Biol | Volume | 8 |
| Issue | 9 | Pages | 945-56 |
| PubMed ID | 16892055 | Mgi Jnum | J:129520 |
| Mgi Id | MGI:3769611 | Doi | 10.1038/ncb1453 |
| Citation | Feng Q, et al. (2006) Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nat Cell Biol 8(9):945-56 |
| abstractText | Cool-1 (cloned-out of library 1) has a key role in regulating epidermal growth factor receptor (EGFR) degradation. Here, we show that Cool-1 performs this function by functioning as both an upstream activator and downstream target for Cdc42. EGF-dependent phosphorylation of Cool-1 enables it to act as a nucleotide exchange factor for Cdc42 and to form a complex with the E3 ligase Cbl, thus regulating Cbl-catalysed EGFR degradation. The EGF-dependent phosphorylation is normally transient; however, Cool-1 phosphorylation is sustained in cells expressing v-Src and is essential for cellular transformation, as well as for v-Src-induced tumour formation in mice. These findings demonstrate that the regulated phosphorylation of Cool-1 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation. |
