| First Author | Matsuki Y | Year | 2007 |
| Journal | EMBO J | Volume | 26 |
| Issue | 3 | Pages | 846-54 |
| PubMed ID | 17255932 | Mgi Jnum | J:119918 |
| Mgi Id | MGI:3703462 | Doi | 10.1038/sj.emboj.7601556 |
| Citation | Matsuki Y, et al. (2007) Novel regulation of MHC class II function in B cells. EMBO J 26(3):846-54 |
| abstractText | The presence of post-translational regulation of MHC class II (MHC II) under physiological conditions has been demonstrated recently in dendritic cells (DCs) that potently function as antigen-presenting cells (APCs). Here, we report that MARCH-I, an E3 ubiquitin ligase, plays a pivotal role in the post-translational regulation of MHC II in B cells. MARCH-I expression was particularly high in B cells, and the forced expression of MARCH-I induced the ubiquitination of MHC II. In B cells from MARCH-I-deficient mice (MARCH-I KO), the half-life of surface MHC II was prolonged and the ubiquitinated form of MHC II completely disappeared. In addition, MARCH-I-deficient B cells highly expressed exogenous antigen-loaded MHC II on their surface and showed high ability to present exogenous antigens. These results suggest that the function of MHC II in B cells is regulated through ubiquitination by MARCH-I. |
