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Protein Domain : Ankyrin repeat and SAM domain-containing protein 1B

Primary Identifier  IPR033636 Type  Family
Short Name  ANKS1B
description  ANKS1B, also known as AIDA-1or EB-1, is predominantly expressed in brain, and acts as a scaffold protein at postsynaptic densities where it plays a role for long-term potentiation []. It affects hippocampal synaptic transmission by regulating NMDA receptor subunit composition at synapses []. ANKS1B interacts with the amyloid precursor protein (APP), widely implicated in the development of Alzheimer's disease [].There are at least five isoforms of ANKS1B, all of which contain two sterile alpha motif (SAM) domains and a PTB domain [, ].

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0 Parent Features

33 Protein Domain Regions