Primary Identifier | IPR033636 | Type | Family |
Short Name | ANKS1B |
description | ANKS1B, also known as AIDA-1or EB-1, is predominantly expressed in brain, and acts as a scaffold protein at postsynaptic densities where it plays a role for long-term potentiation []. It affects hippocampal synaptic transmission by regulating NMDA receptor subunit composition at synapses []. ANKS1B interacts with the amyloid precursor protein (APP), widely implicated in the development of Alzheimer's disease [].There are at least five isoforms of ANKS1B, all of which contain two sterile alpha motif (SAM) domains and a PTB domain [, ]. |