| First Author | Wegiel J | Year | 1998 |
| Journal | Brain Res | Volume | 804 |
| Issue | 1 | Pages | 135-9 |
| PubMed ID | 9729335 | Mgi Jnum | J:49613 |
| Mgi Id | MGI:1277753 | Doi | 10.1016/s0006-8993(98)00618-0 |
| Citation | Wegiel J, et al. (1998) Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice. Brain Res 804(1):135-9 |
| abstractText | The numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37% in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for macrophages. Moreover, microglia in the frontal cortex of the op/op mice are smaller and have shorter cytoplasmic processes compared to control mice. Study suggests that CSF-1 plays a role in vivo in the formation and maturation of microglia and has Little or no effect on perivascular cells. (C) 1998 Elsevier Science B.V. All rights reserved. |
