| Primary Identifier | MGI:1919140 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 71890 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable JUN kinase binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including DNA repair; regulation of epithelial to mesenchymal transition; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within DNA repair and cell division. Predicted to be located in nucleoplasm and spindle. Predicted to be part of anaphase-promoting complex and zeta DNA polymerase complex. Is expressed in several structures, including brain; ganglia; genitourinary system; hemolymphoid system gland; and intestine. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group V. Orthologous to human MAD2L2 (mitotic arrest deficient 2 like 2). PHENOTYPE: Homozygous disruption of this gene causes partial lethality between E13.5 and weaning, reduced body size, small testes and ovaries, infertility, and abnormal primordial germ cell apoptosis. Homozygotes for a null allele show increased neuroblast apoptosis and accumulation of double strand breaks. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
