| First Author | Baruch K | Year | 2016 |
| Journal | Nat Med | Volume | 22 |
| Issue | 2 | Pages | 135-7 |
| PubMed ID | 26779813 | Mgi Jnum | J:233342 |
| Mgi Id | MGI:5781278 | Doi | 10.1038/nm.4022 |
| Citation | Baruch K, et al. (2016) PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease. Nat Med 22(2):135-7 |
| abstractText | Systemic immune suppression may curtail the ability to mount the protective, cell-mediated immune responses that are needed for brain repair. By using mouse models of Alzheimer's disease (AD), we show that immune checkpoint blockade directed against the programmed death-1 (PD-1) pathway evokes an interferon (IFN)-gamma-dependent systemic immune response, which is followed by the recruitment of monocyte-derived macrophages to the brain. When induced in mice with established pathology, this immunological response leads to clearance of cerebral amyloid-beta (Abeta) plaques and improved cognitive performance. Repeated treatment sessions were required to maintain a long-lasting beneficial effect on disease pathology. These findings suggest that immune checkpoints may be targeted therapeutically in AD. |
