| First Author | Slütter B | Year | 2013 |
| Journal | Immunity | Volume | 39 |
| Issue | 5 | Pages | 939-48 |
| PubMed ID | 24238342 | Mgi Jnum | J:208985 |
| Mgi Id | MGI:5565523 | Doi | 10.1016/j.immuni.2013.09.013 |
| Citation | Slutter B, et al. (2013) Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity 39(5):939-48 |
| abstractText | Inducing memory CD8(+) T cells specific for conserved antigens from influenza A virus (IAV) is a potential strategy for broadly protective vaccines. Here we show that memory CD8(+) T cells in the airways played an important role in early control of IAV. Expression of the chemokine receptor CXCR3 was critical for memory CD8(+) T cells to populate the airways during the steady state and vaccination approaches were designed to favor the establishment of memory CD8(+) T cells in the airways. Specifically, we found that interleukin-12 (IL-12) signaling shortly after immunization limited CXCR3 expression on memory CD8(+) T cells. Neutralization of IL-12 or adjuvants that did not induce high amounts of IL-12 enhanced CXCR3 expression, sustained airway localization of memory CD8(+) T cells, and resulted in superior protection against IAV. |
