| First Author | Capanna E | Year | 1976 |
| Journal | Chromosoma | Volume | 58 |
| Issue | 4 | Pages | 341-53 |
| PubMed ID | 1001158 | Mgi Jnum | J:23091 |
| Mgi Id | MGI:70886 | Doi | 10.1007/BF00292842 |
| Citation | Capanna E, et al. (1976) Robertsonian metacentrics in the mouse. Chromosoma 58(4):341-53 |
| abstractText | A survey is given on the occurrence, the geographic origin and the arm composition of 27 Robertsonian fusion metacentric chromosomes of wild populations of the mouse. Their study is of twofold interest: a) it is possible to introduce these naturally occuring metacentrics in laboratory strains for experimental use. At present, altogether 34 metacentric chromosomes of different composition are available including 7 cases of metacentrics known form laboratory strains of the mouse. b) With the search for metacentrics in the mouse and with their identification insights are permitted in the role of Robertsonian changes in the course of mammalian evolution--Several separate populations of the mouse with different sets of multiple (up to 9) metacentrics have been found in Switzerland and Italy. Some of the individual metacentrics may occur in different populations. The participation of an acrocentric autosome in the formation of metacentrics seem to be at random, but the sex chromosomes are never included in a metacentric.--Homology of the arms involved in metacentrics is conserved, so that in meiosis of interpopulation hybrids is due to mechanisms of segregational imbalance and subsequent prenatal elimination of fetal offspring, but it follows also the pattern of male limited hybrid sterility.--From an evolutionary view point, karyotype rearrangements of Robertsonian type may initiate reproductive isolation, which prepares the ground for further genetic diversification and, as in the case of the mouse, of incipient speciation. |
