| Primary Identifier | MGI:7563974 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Umod |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A C to A change at position 556 (c.C556A) resulting in an arginine to serine substitution at amino acid 186 (p.R186S) was introduced in the zona pellucida C domain. An FRT-flanked neomycin resistance cassette was also inserted and was removed via flp-mediated recombination. This corresponds to the R185S mutation identified in individuals with early-onset autosomal dominant tubulointerstitial kidney disease. |
