| First Author | Higashine K | Year | 2018 |
| Journal | Neurosci Lett | Volume | 686 |
| Pages | 87-93 | PubMed ID | 30176341 |
| Mgi Jnum | J:270233 | Mgi Id | MGI:6203494 |
| Doi | 10.1016/j.neulet.2018.08.049 | Citation | Higashine K, et al. (2018) Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF. Neurosci Lett 686:87-93 |
| abstractText | Brain- and testis-specific immunoglobulin superfamily (BT-IgSF) (also known as IgSF11), one of the immunoglobulin superfamily proteins, is a cell adhesion molecule, expressed in the developing cerebellum. We hypothesized that BT-IgSF might have some function in the development of cerebellum, although the physiological roles of BT-IgSF in the cerebellum remain unclear. To investigate the role of BT-IgSF in the development of mouse cerebellum, we first determined the presence of BT-IgSF in the newborn mouse cerebellum; its expression level was found to be much higher than that in the adults. BT-IgSF was abundantly expressed in the molecular layer, where cerebellar granule cell precursors (CGCPs) are in the differentiation stage during migration. We subsequently analyzed the effects of BT-IgSF-knockdown and -overexpression on the proliferation and differentiation of primary cultured CGCPs. BT-IgSF suppressed the proliferation of CGCPs, and promoted their differentiation into cerebellar granule cells. Taken together, our results suggested that BT-IgSF is one of the important cell adhesion molecules that regulate the developmentof mouse cerebellum. |
