| Primary Identifier | IPR029586 | Type | Family |
| Short Name | Shc1/ShcA |
| description | The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].Shc1 (ShcA) adaptor transduces phosphotyrosine-dependent signals downstream of receptor tyrosine kinases (RTK) and non-RTKs, which regulates signalling pathways in breast cancer cells []. Its SH2 domain is critical for tumour survival during mammary tumorigenesis [], while its PTB domain functions as a biological sensor of phosphotyrosine signalling during breast cancer progression []. Shc1 is required for transforming growth factor beta (TGF-beta)-induced breast cancer cell migration, invasion, and metastasis []. It is also involved in signalling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis []. |
