Primary Identifier | MGI:1925662 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 78412 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in double-strand break repair via nonhomologous end joining and immunoglobulin V(D)J recombination. Is active in site of double-strand break. Is expressed in several structures, including adipose tissue; alimentary system; eye; male reproductive gland or organ; and nervous system. Orthologous to human CYREN (cell cycle regulator of NHEJ). PHENOTYPE: Homozygous knockout increases sensitivity to ionizing radiation and affects B cell class switching recombination. [provided by MGI curators] |