| First Author | Fukuda T | Year | 1994 |
| Journal | Brain Res | Volume | 639 |
| Issue | 2 | Pages | 325-8 |
| PubMed ID | 7911392 | Mgi Jnum | J:17181 |
| Mgi Id | MGI:65232 | Doi | 10.1016/0006-8993(94)91747-7 |
| Citation | Fukuda T (1994) 2-Methyl-1,2,3,4-tetrahydroisoquinoline does dependently reduce the number of tyrosine hydroxylase-immunoreactive cells in the substantia nigra and locus ceruleus of C57BL/6J mice. Brain Res 639(2):325-8 |
| abstractText | 2-Methyl-1,2,3,4-tetrahydroisoquinoline (2-MTIQ) was administered chronically to C57BL/6J mice. Light and electron microscopic examinations revealed atrophic neurons restricted to the central portion of the substantia nigra pars compacta (SNc) and pars lateralis as well as a reduction in tyrosine hydroxylase immunoreactivity, which showed a significant inverse correlation with the dose administered in the SNc. 2-MTIQ may be a candidate endogenous or environmental factor that induces parkinsonism. |
