| First Author | Cheng HJ | Year | 2001 |
| Journal | Neuron | Volume | 32 |
| Issue | 2 | Pages | 249-63 |
| PubMed ID | 11683995 | Mgi Jnum | J:72426 |
| Mgi Id | MGI:2152659 | Doi | 10.1016/s0896-6273(01)00478-0 |
| Citation | Cheng HJ, et al. (2001) Plexin-a3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron 32(2):249-63 |
| abstractText | Plexins are receptors implicated in mediating signaling by semaphorins, a family of axonal chemorepellents. The role of specific plexins in mediating semaphorin function in vivo has not, however, yet been examined in vertebrates. Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons. Using a chimeric receptor construct, we provide evidence that plexin-A3 can transduce a repulsive signal in growth cones in vitro. Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo. |
