| First Author | Pullen AM | Year | 1989 |
| Journal | J Immunol | Volume | 142 |
| Issue | 9 | Pages | 3033-7 |
| PubMed ID | 2496158 | Mgi Jnum | J:9734 |
| Mgi Id | MGI:58191 | Doi | 10.4049/jimmunol.142.9.3033 |
| Citation | Pullen AM, et al. (1989) Evidence that Mls-2 antigens which delete V beta 3+ T cells are controlled by multiple genes. J Immunol 142(9):3033-7 |
| abstractText | V beta 3+ T cells are eliminated in Mls-2a mice carrying some, but not all, H-2 types. Analysis of AKXD and BXD recombinant inbred strains showed that Mls-2a (formerly Mlsc) was not the product of a single gene and suggested that at least two non-H-2 genes control V beta 3 levels. Studies of the progeny of a B10.BR x (C3H/HeJ x B10.BR)F1 backcross confirmed the existence of two V beta 3+ T cell deleting genes: one unlinked and one linked to Ly-7, which we propose be called Mls-2 and Mls-3, respectively. Mls-2a induces partial deletion of V beta 3+ T cells with a bias toward deleting CD4+ cells. It stimulates V beta 3+ hybrids and may be linked to Mtv-13 on chromosome 4. A third non-H-2 gene is implicated in enhancing the presentation of Mls-2a. Mls-3a causes elimination of all V beta 3+ T cells in H-2k and H-2d mice but poorly stimulates V beta 3+ hybrids. |
