| Primary Identifier | MGI:88174 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 12151 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; promoter-specific chromatin binding activity; and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule biosynthetic process; and regulation of adaxial/abaxial pattern formation. Located in nuclear body. Part of PRC1 complex and heterochromatin. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to human BMI1 (BMI1 proto-oncogene, polycomb ring finger) and COMMD3-BMI1 (COMMD3-BMI1 readthrough). PHENOTYPE: Homozygous null mutants display severe hematopoietic defects, neurological abnormalities, posterior transformation, and infertility in both sexes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
