Primary Identifier | MGI:2155791 | Allele Type | QTL |
Gene | Sles1 | Inheritance Mode | Recessive |
Strain of Origin | NZW | Is Recombinase | false |
Is Wild Type | false |
description | Sles1 interacts with Sles2, Sles3, and Sles4 in a cumulative fashion. NZW-derived alleles at Sles1 suppress the anti-nuclear autoantibody producing phenotype in animals with NZW-derived alleles at Sle1. |
molecularNote | This allele confers resistance to systemic lupus erythematosus compared to C57BL/6. |