First Author | Johnson FM | Year | 1981 |
Journal | Biochem Genet | Volume | 19 |
Issue | 5-6 | Pages | 599-615 |
PubMed ID | 6457600 | Mgi Jnum | J:6623 |
Mgi Id | MGI:55098 | Doi | 10.1007/BF00484629 |
Citation | Johnson FM, et al. (1981) A null mutation at the mouse Phosphoglucomutase-1 locus and a new locus Pgm-3. Biochem Genet 19(5-6):599-615 |
abstractText | A null mutation at the phosphoglucomutase locus (Pgm-1) was discovered by electrophoretic analysis of the inbred mouse strain C57BL/6J. The null allele (Pgm-1n) was shown to segregate as a Mendelian unit alternative to the Pgm-1a and Pgm-1b alleles. Mice expressing the Pgm-1n allele, either in the heterozygous or homozygous state, are viable, healthy, and fertile. The occurrence of the Pgm-1n mutant revealed a previously unreported genetic locus (Pgm-3) that controls the expression of a third phosphoglucomutase. Two electrophoretically expressed alleles of Pgm-3 (inherited without dominance) are found in the inbred mouse strains C57BL/6J and DBA/2J. Linkage observed between the Pgm-3 locus, the dilute locus (d) and the cytoplasmic malic enzyme locus (Mod-1) has allowed assignment of the Pgm-3 locus to chromosome 9. A striking tissue specific expression of Pgm-1 and Pgm-3 was observed. Products of the Pgm-3 locus were detected in kidney, testes, brain, and heart. In contrast, Pgm-1 controlled isozymes were present in kidney, spleen, ovaries, and erythrocytes. |