| First Author | Martinez GJ | Year | 2016 |
| Journal | J Immunol | Volume | 196 |
| Issue | 5 | Pages | 2015-9 |
| PubMed ID | 26851216 | Mgi Jnum | J:294367 |
| Mgi Id | MGI:6455924 | Doi | 10.4049/jimmunol.1501841 |
| Citation | Martinez GJ, et al. (2016) Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection. J Immunol 196(5):2015-9 |
| abstractText | Follicular CD4(+) Th (Tfh) cells provide B cell help in germinal center reactions that support class switching, somatic hypermutation, and the generation of high-affinity Abs. In this article, we show that deficiency in NFAT1 and NFAT2 in CD4(+) T cells leads to impaired germinal center reactions upon viral infection because of reduced Tfh cell differentiation and defective expression of proteins involved in T/B interactions and B cell help, including ICOS, PD-1, and SLAM family receptors. Genome-wide chromatin immunoprecipitation data suggest that NFAT proteins likely directly participate in regulation of genes important for Tfh cell differentiation and function. NFAT proteins are important TCR and Ca(2+)-dependent regulators of T cell biology, and in this article we demonstrate a major positive role of NFAT family members in Tfh differentiation. |
