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Comment :

Type  MGI:General Description  mice exhibit spike wave discharge (SWD) accompanied by behavior arrest unlike wild-type mice the average incidence of SWD is higher than in Scn8amed heterozygotes but lower than in Scn8a8J heterozygotes ethosuximide treatment results in 11-fold fewer and shorter SWD compared to a 3-fold increase in frequencies following saline treatment the frequency of SWD during slow-wave sleep and paradoxical SWD are higher during the dark cycle than during the light cycle