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Publication : Audiogenic seizure sensitivity in mouse lines genetically selected for high versus low blood magnesium levels.

First Author  Motta R Year  1999
Journal  Behav Genet Volume  29
Issue  2 Pages  125-30
PubMed ID  10405461 Mgi Jnum  J:55928
Mgi Id  MGI:1339564 Doi  10.1023/a:1021612623060
Citation  Motta R, et al. (1999) Audiogenic seizure sensitivity in mouse lines genetically selected for high versus low blood magnesium levels. Behav Genet 29(2):125-30
abstractText  The MGH and MGL mouse lines, genetically selected for high and low blood magnesium (Mg) levels, respectively, exhibit marked differences for characteristics expected to be related to blood Mg levels, such as increased stress sensitivity and stress-induced aggressivity in MGL mice. However, although Mg deficiency experimentally induced by low oral Mg intake has been shown previously to increase susceptibility to audiogenic seizures, MGL were less sensitive to audiogenic seizures than MGH mice. The MGH-MGL lines may, therefore, provide a beneficial and complementary model for the study of the relationships between audiogenic seizures and blood Mg levels.
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