| First Author | Kumar H | Year | 2009 |
| Journal | Biochem J | Volume | 420 |
| Issue | 1 | Pages | 1-16 |
| PubMed ID | 19382893 | Mgi Jnum | J:150494 |
| Mgi Id | MGI:3850880 | Doi | 10.1042/BJ20090272 |
| Citation | Kumar H, et al. (2009) Pathogen recognition in the innate immune response. Biochem J 420(1):1-16 |
| abstractText | Immunity against microbial pathogens primarily depends on the recognition of pathogen components by innate receptors expressed on immune and non-immune cells. Innate receptors are evolutionarily conserved germ-line-encoded proteins and include TLRs (Toll-like receptors), RLRs [RIG-I (retinoic acid-inducible gene-I)-like receptors] and NLRs (Nod-like receptors). These receptors recognize pathogens or pathogen-derived products in different cellular compartments, such as the plasma membrane, the endosomes or the cytoplasm, and induce the expression of cytokines, chemokines and co-stimulatory molecules to eliminate pathogens and instruct pathogen-specific adaptive immune responses. In the present review, we will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways. |
