Primary Identifier | MGI:104745 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 20370 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Acts upstream of or within several processes, including excitatory postsynaptic potential; nervous system development; and regulation of protein kinase C signaling. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Orthologous to human SEZ6 (seizure related 6 homolog). PHENOTYPE: Mice homozygous for a null allele exhibit increased short dendrites, decreased excitatory synaptic signaling, resistance to pharmacologically induces seizures, decreased activity and impaired learning and coordination. [provided by MGI curators] |