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Protein Coding Gene : Man2a1 mannosidase 2, alpha 1

Primary Identifier  MGI:104669 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  17158
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables hydrolase activity, hydrolyzing N-glycosyl compounds and mannosidase activity. Acts upstream of or within several processes, including N-glycan processing; lung alveolus development; and retina morphogenesis in camera-type eye. Located in Golgi membrane; cis-Golgi network; and extracellular space. Is expressed in adrenal gland; gland; and white fat. Used to study congenital dyserythropoietic anemia and systemic lupus erythematosus. Orthologous to human MAN2A1 (mannosidase alpha class 2A member 1).
PHENOTYPE: Homozygous mutation of this gene results in premature death, dyserythropoiesis, systemic autoimmune disease, including an increase in serum immunoglobulins, glomerulonephritis, and hematuria, [provided by MGI curators]
  • synonyms:
  • Mana-2,
  • MGD-MRK-27032,
  • Map-2,
  • MGD-MRK-12110,
  • Man2a1,
  • mannosidase 2, alpha 1,
  • alpha mannosidase 2,
  • MGD-MRK-12109,
  • Mana2

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For