| First Author | Ma L | Year | 2002 |
| Journal | Genomics | Volume | 80 |
| Issue | 6 | Pages | 662-72 |
| PubMed ID | 12504857 | Mgi Jnum | J:80804 |
| Mgi Id | MGI:2447226 | Doi | 10.1006/geno.2002.7012 |
| Citation | Ma L, et al. (2002) Cloning and Characterization of Disc1, the Mouse Ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics 80(6):662-72 |
| abstractText | We cloned the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1), a candidate gene for schizophrenia. Disc1 is 3163 nucleotides long and has 60% identity with the human DISC1. Disc1 encodes 851 amino acids and has 56% identity with the human protein. Disc1 maps to the DISC1 syntenic region in the mouse, and genomic structure is conserved. A Disc1 splice variant deletes a portion of Disc1 beginning at amino acids orthologous to the human truncation. Bioinformatic analysis and cross-species comparisons revealed sequence conservation distributed across the genes and conservation of leucine zipper and coiled-coil domains in both orthologs. In situ hybridization in adult mouse brain revealed a restricted expression pattern, with highest levels in the dentate gyrus of the hippocampus and lower expression in CA1-CA3 of the hippocampus, cerebellum, cerebral cortex, and olfactory bulbs. Identification of Disc1 will facilitate the study of DISC1's function and creation of mouse models of DISC1 disruption. |
